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Aluminum Chloride is Tolerated in Less Than 30% of Patients with Hyperhidrosis of the Underarms - Botox or Aluminum Chloride ?

By: Hratch Karamanoukian, MD and Raffy Karamanoukian, MD

July 27, 2008

Effectiveness of Botox and Aluminum Chloride for Hyperhidrosis of the Underarms ?
As is well known, first line therapy for hyperhidrosis of the underarms is topical agents such as aluminum chloride. Botulinum toxin type A (BTX-A) is FDA-approved for the treatment of primary hyperhidrosis of the underarms which is unresponsive to topical therapy.
Researchers at the Department of Dermatology, Saint Louis University School of Medicine, St. Louis, MO investigated BTX-A with .20% aluminum chloride in a prospective randomized fashion for 12 weeks in patients with primary focal axillary hyperhidrosis.
At 1 month follow-up, 92% of the patients in the BTX-A group achieved treatment response compared with 33% of the subjects in the aluminum chloride treated group.  
The researchers, lead by Dr. Flanagan showed that treatment with BTX-A was more effective and provided greater patient satisfaction than with aluminum chloride topical therapy for axillary hyperhidrosis. As well, it was shown that aluminum chloride was effective and tolerated in only 29% of patients.
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For more information about hyperhidrosis (excessive sweating) , as well as surgical and non-surgical hyperhidrosis treatment options, contact Dr. Karamanoukian at The Center for Excessive Sweating, a National Center of Excellence for Hyperhidrosis Treatment by email or by phone at (716) 839-3638.

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