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Secondary Hyperhidrosis - Side Effect of Effexor XR - Venlafaxine XR

By: Hratch Karamannoukian MD and Raffy Karamanoukian MD

August 9, 2008

Hyperhidrosis News - Effexor XR and Hyperhidrosis - A Common Side Effect

Venlafaxine (Effexor) and Hyperhidrosis – A New Study Concludes that Hyperhidrosis is a Major Side Effect of Effexor (Venlafaxine)

Venlafaxine (Effexor) is an antidepressant of the serotonin norepi reuptake inhibitor class (SNRI). It was introduced in 1993 by Wyeth and is prescribed for the treatment of major depression and anxiety disorders. It has been associated with suicide and as such, is not recommended as a first line treatment for depression. However, it is often effective for depression not responding to SSRIs. Effexor is the 6th most widely-used antidepressant based on the number of retail prescriptions dispensed in the United States in 2006.


A research study comparing Effexor XR to bupripion XR in an eight-week, placebo-controlled, double-blind comparison showed that the most frequently reported adverse events were dry mouth and insomnia for bupropion XR, and nausea, hyperhidrosis, fatigue, and insomnia for venlafaxine XR (Effexor XR).


This research study was published by Dr. Hewett et al. in the July edition of the journal Psychopharmacology (July 17th).


For more information about hyperhidrosis contact Dr. H Karamanoukian at and Dr. Raffy at



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For more information about hyperhidrosis (excessive sweating) , as well as surgical and non-surgical hyperhidrosis treatment options, contact Dr. Karamanoukian at The Center for Excessive Sweating, a National Center of Excellence for Hyperhidrosis Treatment by email or by phone at (716) 839-3638.

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