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What is the Genetics of Primary Hyperhidrosis ?

By: Hratch Karamanoukian, MD and Raffy Karamanoukian, MD

August 16, 2008

What is the Genetics of Hyperhidrosis ? 
To date, there are few genetic studies on palmoplantar hyperhidrosis.
Japanese researchers have completed genetic linkage analysis of 11 families including 42 affected and 40 unaffected members using genome-wide DNA polymorphic markers to identify the disease locus for palmoplantar hyperhidrosis.
Mapping of the primary palmoplantar hyperhidrosis was between D14S1070 and D14S990 and at maximum to about a 30-cM interval between D14S1070 and D14S70. This is the first report of systemic mapping of the PPH locus.
We can now say that patients with palmoplantar hyperhidrosis have a genetic predisposition and that the gene has been located and mapped. This article was published in the American Journal of Medical Genetics, volume 140, pages 567-572.
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For more information about hyperhidrosis (excessive sweating) , as well as surgical and non-surgical hyperhidrosis treatment options, contact Dr. Karamanoukian at The Center for Excessive Sweating, a National Center of Excellence for Hyperhidrosis Treatment by email or by phone at (716) 839-3638.

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